Trachette Jackson

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Trachette L. Jackson is Full Professor in the Mathematics Department, who specializes in Computational Cancer Research or Mathematical Oncology.   A focus of Dr. Jackson’s research has been achieving a unified understanding of how signaling molecules, cells, and micro-environmental structures coordinate to control blood vessel generation, morphology and functionality during tumor growth.  Her work aims to biochemically and biomechanically characterize the collective motion vascular endothelial cells, one of most important cell types involved in cancer development due to their role in angiogenesis.

With an eye toward addressing critical challenges associated with targeted molecular therapeutics, for example determining which drugs are the best candidates for clinical trials, Dr. Jackson also develops multiscale mathematical models that are designed to optimize the use of targeted drug treatment strategies.  These mathematical models connect the molecular events associated with tumor growth and angiogenesis with the temporal changes in tumor cell and endothelial cell proliferation, migration and survival, and link these dynamics to tumor growth, vascular composition, and therapeutic outcome.

trachettejackson

Jon Zelner

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Jon Zelner is an Assistant Professor in the Dept. of Epidemiology and Center for Social Epidemiology and Population Health in the UM School of Public Health. His work focuses on understanding the joint contributions of social, biological, and environmental factors to infectious disease transmission dynamics, with a particular focus on Tuberculosis (TB) transmission in high-burden contexts.

To do this, Jon uses mathematical and individual-based models to guide the design of studies and statistical tools for extracting information on infectious disease transmission from real-world spatiotemporal data. This ranges from small-scale simulation of household and community-based transmission to large-scale individual-based models of infectious disease transmission in megacities. A recurring methodological theme of this work is the challenge in navigating the tradeoff between fidelity to real-world processes and the need for parsimonious explanation of observable phenomena.

Tuberculosis hotspot in Lima, Peru

A hotspot of elevated incidence of multi-drug resistant tuberculosis (MDR-TB) in Lima, Peru is shown in red. Points indicate the location of TB cases; those marked ‘x’ are MDR-TB cases.

 

 

Heather Mayes

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Heather Mayes is an Assistant Professor in the Department of Chemical Engineering. Her research group uses multi-scale modeling to discover protein-sugar interactions and to harness them for renewable energy and improved health. The study of carbohydrate-protein interactions is an important step to create renewable fuels and chemicals from non-food biomass, and the results can be applied to several human diseases, including cancer and autoimmune disorders. Prof. Mayes uses computational tools in her research, including quantum mechanics, molecular dynamics, and rare-event sampling methods. She collaborates with experimental groups to understand past and guide future wet-lab studies to advance renewable chemicals and fuels, as well as disease understanding.

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Multiscale simulation to uncover mechanisms behind protein-sugar interactions, such as how the T. reesi Cel6A enzyme coordinates making and breaking four bonds for cellulose hydrolysis.

 

 

Angela Violi

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Angela Violi is a Professor in the Department of Mechanical Engineering, and adjunct faculty in Chemical Engineering, Biophysics, Macromolecular Science and Engineering, and Applied Physics. The research in the group of Violi is focused on the application of statistical mechanics and computational methods to chemically and physically oriented problems in nanomaterials and biology. The group investigates the formation mechanisms of nanomaterials for various applications, including energy and biomedical systems, and the dynamics of biological systems and their interactions with nanomaterials.

violinanoparticlegenesis

Michal Zochowski

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Michal Zochowski is a Professor in the Departments of Physics and Biophysics Program. His research interests lie in the intersection of physics and neuroscience. His group focuses on understanding the mechanisms of the formation of spatio-temporal patterns in coupled dynamical systems, their applicability and role during information processing in the brain. They use theoretical and experimental approaches, including computational modeling of various brain processes including memory storage, consolidation and its retrieval.

Marisa Eisenberg

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Marisa Eisenberg is an assistant professor in the Department of Epidemiology, and in the Department of Mathematics. Her research revolves around mathematical epidemiology, focus on using and developing parameter estimation and identifiability techniques to model disease dynamics. Her group builds multi-scale models of infectious disease, including HPV, cholera and other environmentally driven diseases.

marisaeisenbergresearchpicture

Likelihood surface exhibiting issues of unidentifiability—colors indicate goodness-of-fit, and the white line shows the values taken by an optimization algorithm as it navigates the surface.

Silas Alben

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Silas Alben is an Associate Professor in the Department of Mathematics, and the Director of the Applied & Interdisciplinary Mathematics program. He uses theoretical analysis, and develops numerical methods and models of problems arising from biology, especially biomechanics and engineering. Some of his group’s current applications are piezoelectric flags, flag fluttering in inviscid channel flow, snake locomotion and jet-propelled swimming.

Equilibrium configurations of actuated bilayers with general initial shapes. S. Alben, Adv. Comp. Math., 2014

Equilibrium configurations of actuated bilayers with general initial shapes. S. Alben, Adv. Comp. Math., 2014

George Alter

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George Alter is Research Professor at ICPSR and the Population Studies Center and Professor of History at the University of Michigan. His research grows out of interests in the history of the family, demography, and economic history, and recent projects have examined the effects of early life conditions on health in old age and new ways of describing fertility transitions. He is also involved in international efforts to promote research transparency and data sharing.

Victoria Booth

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Victoria Booth is an Associate Professor in the Department of Mathematics and the Department of Anesthesiology. Her interdisciplinary research in mathematical and computational neurosciences focuses on constructing and analyzing biophysical models of neurons and neural networks in order to quantitatively probe experimental hypothesis and provide experimentally-testable predictions. Her research provides continuous reciprocal interactions between modeling and experimental results.

Prof. Booth and her colleagues are constructing neurophysiologically based models of the neuronal networks and neurotransmitter interactions in the brainstem and the hypothalamus that regulate wake and sleep states. She is also addressing the question of the influence of intrinsic neuron properties and network topology on the generation of spatio-temporal activity patterns in large-scale neural networks.

Brian Denton

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Brian Denton is a Professor in the Department of Industrial & Operations Engineering, and a member of the Institute for Healthcare Policy and Innovation. His primary research interests are in optimization under uncertainty with applications to medical decision-making. He uses stochastic programming, simulation-optimization and Markov decision processes to optimize decisions regarding detection, treatment, and prevention of chronic diseases, including cancer, diabetes and heart disease.