Subject specific blood flow modeling has developed notably over the last decades. From the pioneering academic work in the 1990s to today’s landscape in which computer-based simulations to assess the severity of coronary disease have been recently approved by the FDA, the progress has been remarkable. The biggest challenge in the field of blood flow simulation is the lack of physiologic data to inform the boundary conditions (at inflow and outflow branches) as well as the mechanical properties (e.g., distribution of stiffness and perivascular tissue support) of the vascular model.