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Omar Ahmed

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The Ahmed lab studies behavioral neural circuits and attempts to repair them when they go awry in neuropsychiatric disorders. Working with patients and with transgenic rodent models, we focus on how space, time and speed are encoded by the spatial navigation and memory circuits of the brain. We also focus on how these same circuits go wrong in addiction, epilepsy and traumatic brain injury.

In addition to electrophysiology in rodents and humans, we use imaging and photoactivation techniques to record and alter neuronal activity as rodents navigate custom-designed virtual reality environments. We also work on novel computational techniques to model and analyze our immensely large electrophysiology and imaging datasets to better understand how specific behaviors are encoded by neural circuits.

Dr. Ahmed received both his undergraduate and Ph.D. degrees in Neuroscience from Brown University. He then worked with epilepsy patients at Massachusetts General Hospital during his postdoctoral work, before joining the faculty at the University of Michigan as an Assistant Professor.

Polar plots showing the rhythmic phases of spikes fired by human neurons, revealing systematic variations across space and time.

David Nordsletten

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Dr. Nordsletten is an Associate Professor in the Departments of Biomedical Engineering and Cardiac Surgery. He is also a Reader in cardiovascular biomechanics at King’s College London, and is the recipient of the EPSRC HTCA leadership fellowship. His research focuses on the novel application of biomechanics integrated with magnetic resonance imaging (MRI) for the advancement of human cardiovascular health. This broad focus encompasses a range of projects spanning from numerical methods development through to direct analysis of medical imaging data for diagnostics in cardiovascular disease.

Computational biomechanical model of the biventricular heart, showing the orientation of muscle fibres within the tissue.

Grenmarie Agresar

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Graduation Year

1997

Thesis Title

A computational environment for the study of circulating cell mechanics and adhesion

Supervisor

Jennifer Linderman

Current Job

Instructional Consultant at the University of Michigan

Scott Lempka

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Scott Lempka is an Assistant Professor in the Department of Biomedical Engineering and director of the Neuromodulation Laboratory. The Neuromodulation Lab focuses on clinical neurostimulation (a.k.a. neuromodulation) therapies, such as spinal cord stimulation and deep brain stimulation. These therapies are used to treat a variety of neurological disorders, such as chronic pain and Parkinson’s disease. In these therapies, metal electrodes are used to apply electrical pulses that override pathological activity in the nervous system. The Neuromodulation Lab develops computer models of the electric fields generated by the stimulation and the direct neural response. These computer models are combined with clinical data, such as quantitative sensory testing and functional neuroimaging, to understand the effects of various therapies – why they work in some patients and not in others.

Lempka-MICDE-Figure-01

Denise Kirschner

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Denise Kirschner is a Professor in the Department of Microbiology and Immunology.  She serves as founding co-director of the Center for Systems Biology, is affiliated with both the Center for the Study of Complex Systems and  the Center for Computational Medicine and Bioinformatics. Her research involves the modeling of immunological responses in infectious diseases, focusing on questions related to host-pathogen interactions. The pathogens she studies include both bacteria (Mycobacterium tuberculosis) and HIV-1. Such pathogens have evolved strategies to evade or circumvent the host-immune response and the lab’s goal is to understand the complex dynamics involved and develop optimal treatment and vaccine strategies.

Karl Grosh

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Professor Grosh research spans various aspects of structural acoustics, mechanics, biomechanics and linear/nonlinear vibrations. Current research involves Cochlear mechanics (experiments and modeling of the mechanics of soft tissue and tissue growth), electroacoustic transducers, and computational and analytic methods for solving interior viscous fluid-structure interaction problems.

Jennifer Linderman

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The Linderman group works in the area of computational biology, especially in developing multi-scale models that link molecular, cellular and tissue level events.   Current areas of focus include: (1) hybrid multi-scale agent-based modeling to simulate the immune response to Mycobacterium tuberculosis and identify potential therapies, (2) models of signal transduction, particularly for G-protein coupled receptors, and (3) multi-scale agent-based models of cancer cell chemotaxis.

Hybrid multi-scale model of the immune response to Myobacterium tuberculosis in the lung. Selected immune cell behaviors and interactions captured by the model are shown. Not shown are single cell receptor/ligand dynamics involving the pro-inflammatory cytokine tumor necrosis factor (TNF) and the anti-inflammatory cytokine interleukin 10 (IL-10).

Hybrid multi-scale model of the immune response to Myobacterium tuberculosis in the lung. Selected immune cell behaviors and interactions captured by the model are shown. Not shown are single cell receptor/ligand dynamics involving the pro-inflammatory cytokine tumor necrosis factor (TNF) and the anti-inflammatory cytokine interleukin 10 (IL-10).

C. Alberto Figueroa

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Alberto Figueroa is an Associate Professor with a joint appointment in Biomedical Engineering and Surgery. He works on computational methods for patient-specific cardiovascular simulation.figueroa_image-264x300

Modeling the function of the cardiovascular system in health and disease represents a fascinating scientific challenge. This challenge can only be addressed by combining a deep understanding of the physiologic, biologic, engineering and mathematical principles involved.Our lab uses medical image processing, high performance computational fluid dynamics simulation, and multi-scale modeling to simulate blood flow in the human body. Our specific areas of interest are surgical planning, disease research, arterial growth and remodeling, and medical device design and performance evaluation.