Portrait of Brendon Watson

Brendon Watson

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We use electrophysiologic, behavioral and computational methods to understand brain-behavior linkages in rodents. We aim to answer questions aimed both at fundamental neurobiological questions as well as the role of neural circuit electrophysiology in disease. We use an approach informed by an understanding of neuronal microcircuit dynamics, macrocircuit connectivity and organism-level behavior to connect between the level of single neurons, networks of those neurons and animal behavior.
Our electrophysiologic approaches extract complex neural spiking dynamics from across populations of neurons simultaneously as animals freely behave. We then link those population spiking dynamics with multi-metric behavioral dynamics to bridge brain and behavior. The complex datasets data created are then analyzed both using traditional methods (traditional statistics and standard event-triggered analyses) and machine learning methods to enable extraction of novel dynamics.