A proposed public registry
The Scientific Challenge Atlas
Mapping the machine-accessible frontier of science
AI will increasingly be able to make scientific advances that matter for humanity. This is uncharted territory. Scientists, and the communities that support them, are still trying to understand the scale and character of what can be accomplished.
Overview
A mixed landscape, and no map of it
A basic difficulty is that the landscape is mixed. Some scientific advances may be reachable by a sufficiently strong intelligence working from humanity’s current scientific record, public data, and executable computation. Others still require gathering new information about the world through new experiments or observations. We do not yet have a map of which advances fall into which category.
The distinction
Two categories of challenge
It is worth pausing on the significance of that distinction.
Waiting on the world
If a challenge still requires new facts about the world, then AI can help, but progress must wait on physical events.
Waiting on the decision
If the decisive evidence is already available, the problem changes category. This does not mean the answer is already visible. It may require a deep new theory, proof, abstraction, or model. But with sufficiently strong AI, the advance no longer depends on building a complex research program to gather new information. It depends on deciding to attack it, and spending enough compute.
The registry
What the atlas would do
The Scientific Challenge Atlas would provide a map of that class. It would be a public registry of important open scientific questions in the intelligence-reachable part of the landscape. Some entries may be solved by exhaustive synthesis. Others may require a new proof, model comparison, bound, or conceptual reframing. The common feature is that the needed information about the world is already available.
The atlas would:
- Show the span of meaningful scientific advances that strong AI could plausibly make without first waiting for new experiments or observations.
- Identify challenges whose solution may now be limited mainly by compute, search, and verification.
- Estimate the rough reasoning, search, coding, and compute burden required for each advance.
- Provide a public, disciplined way to evaluate the significance of AI for meaningful scientific advances.
The findings would inform important decisions, including how strongly nations should support the use of frontier AI for advances that would improve the prosperity and security of their people.
Precedent
What the Erdős problems showed
This idea is inspired by the role that Erdős problems have played in mathematics. Paul Erdős posed many important problems in compact form. Thomas Bloom’s Erdős Problems database now lists 1,217 problems, with 555 marked solved as of July 24, 2026.
Problems now listed in Thomas Bloom’s Erdős Problems database
Marked solved as of July 24, 2026
Open Erdős problems resolved by a large-scale formal-proof effort, at a cost of a few hundred dollars per problem
Recent AI efforts have shown why this matters. On May 21, 2026, OpenAI announced an AI-assisted breakthrough on Erdős’s planar unit distance problem. Another large-scale formal-proof effort resolved 9 of 353 open Erdős problems at a cost of a few hundred dollars per problem. The broader lesson is that a good public problem list creates a focal point for the community to attack challenges. Science needs an analogous map.
Criteria for entry
The Form
A useful feature of trying AI on the Erdős problems is that it does not require resolving difficult debates about topics like the nature of knowledge or the character of human creativity. They provide the question, the answer shape, and the verification criterion (a sound mathematical proof).
The atlas aims for the same simplicity. Problems that cannot be stated with those criteria, for example because there is no plausible verification path, are excluded from the atlas.
Participants
Collaborating institutions
The Scientific Challenge Atlas is developed in collaboration with the following institutions.
University of MichiganAnn Arbor, Michigan
OpenAISan Francisco, California
Los Alamos National LaboratoryLos Alamos, New Mexico
Argonne National LaboratoryLemont, Illinois