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SUMMARY:PhD Seminar: Pei-Hsun Huang
DESCRIPTION:The Ph.D. in Scientific Computing program is intended for students who will make extensive use of large-scale computation\, computational methods\, or algorithms for advanced computer architectures in their doctoral studies. This seminar series showcases the breadth of research covered by the program.  \nFeatured Speaker:\nPei-Hsun Huang\, PhD Candidate\, Nuclear Engineering & Radiological Sciences and Scientific Computing\nPei-Hsun is a PhD student in Nuclear Engineering & Radiological Sciences working with Professor Annalisa Manera in the Experimental and Computational Multiphase Flow Laboratory. His project involves high-temperature two-phase heat pipe technologies. \nSimulation for the Design of Sodium Heat Pipes Bundle Test Facility for the Application of Microreactors\nThe 20 MW Special Purpose Reactor (SPR) is a heat pipe cooled microreactor that designed for electricity production in remote locations where reliable power grids are not always available. The key to SPR is the alkali metal heat pipes\, which offer entirely passive operation capacity with high mobility. Prior to deployment\, safety analysis with postulated accident scenarios is required for the licensing of SPR. To this regard\, a sufficiently accurate model is crucial to predict the behavior of heat pipes\, and high-resolution data is needed for the safety analysis of SPR. However\, the current existing heat pipe models are either oversimplified or unpractical expensive in view of the difficulty of the simulation with the wick structure and two-phase flow in the heat pipe. Therefore\, high fidelity experimental data is required for model verification in the high temperature heat pipe bundle system. The Michigan Sodium Heat Pipe bundle test facility which serves as a scale-down test facility using ten sodium heat pipes with a triangular array\, was utilized to verify the model for the licensing of SPR. In the talk\, the feasibility analysis using Computer Aided Engineering and Computational Fluid Dynamics for the design of the test facility was addressed. \n\n  \nThis event is part of MICDE’s seminar series featuring Ph.D. students in the Scientific Computing program. This series is open to all. University of Michigan faculty and students interested in computational and data sciences are encouraged to attend. \nQuestions? Email MICDE-events@umich.edu \n 
URL:https://micde.umich.edu/event/phd-seminar-pei-hsun-huang-2/
LOCATION:Rackham Building\, Earl Lewis Room\, 3rd Floor East\, 915 E. Washington St.\, Ann Arbor\, MI\, 48109\, United States
CATEGORIES:Featured Events,MICDE PhD Seminar Series,Seminar
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SUMMARY:PhD Seminar: Shirlyn Wang
DESCRIPTION:The Ph.D. in Scientific Computing program is intended for students who will make extensive use of large-scale computation\, computational methods\, or algorithms for advanced computer architectures in their doctoral studies. This seminar series showcases the breadth of research covered by the program.  \nFeatured Speaker:\nShirlyn Wang\, PhD Candidate\, Applied & Interdisciplinary Mathematics and Scientific Computing\nShirlyn Wang is a Ph.D candidate in Applied and Interdisciplinary Mathematics. Her research interest is in mathematical oncology\, the study of cancer initiation\, progression\, and therapy through data-driven mathematical models and simulations.  \nModeling CTL-mediated Tumor Cell Death Mechanisms and the Activity of Immune Checkpoints in Immunotherapy\nImmunotherapy has dramatically transformed the cancer treatment landscape. Of the variety of types of immunotherapies available\, immune checkpoint inhibitors (ICIs)\, which block inhibitory signals from tumor cells and reinvigorate killing activities of immune cells\, have gained the spotlight. Although ICIs have shown promising results for some patients\, the low response rates in many cancers highlight the challenges of using immune checkpoint blockade as an effective treatment. Cytotoxic T lymphocytes (CTLs) execute their cell-killing function via two distinct mechanisms. The first process is fast-acting and perforin/granzyme-mediated\, and the second is a slower\, Fas ligand (FasL)-driven killing mechanism. There is also evidence suggesting that the preferred killing mechanism by CTLs depends on the antigenicity of tumor cells. To determine the key factors affecting responses to checkpoint blockade therapy\, we constructed an ordinary differential equation model describing in vivo tumor-immune dynamics in the presence of active or blocked PD-1/PDL1 immune checkpoint. Specifically\, we analyzed which aspects of the tumor-immune landscape affect the response to ICIs with endpoints of tumor size and composition in the short and long term. By generating a virtual cohort with heterogeneous tumor and immune attributes\, we also simulated the therapeutic outcomes of immune checkpoint blockade in a largely diverse population. In this way\, we identified key tumor and immune characteristics that are associated with tumor elimination\, dormancy and escape. This talk will also shed light on which fraction of a population potentially responds well to ICIs and ways to enhance therapeutic outcomes with combination therapy. \n\n  \nThis event is part of MICDE’s seminar series featuring Ph.D. students in the Scientific Computing program. This series is open to all. University of Michigan faculty and students interested in computational and data sciences are encouraged to attend. \nQuestions? Email MICDE-events@umich.edu \n 
URL:https://micde.umich.edu/event/phd-seminar-shirlyn-wang/
LOCATION:Rackham Building\, Earl Lewis Room\, 3rd Floor East\, 915 E. Washington St.\, Ann Arbor\, MI\, 48109\, United States
CATEGORIES:Featured Events,MICDE PhD Seminar Series,Seminar
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