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SUMMARY:MICDE Seminar: Denise Kirschner\, Professor\, Microbiology and Immunology\, University of Michigan Medical School
DESCRIPTION:About Denise Kirschner: Dr. Kirschner received her Bachelors\, Masters and PhD in applied mathematics from Tulane University. She did graduate work also at Los Alamos National Labs and a postdoctoral fellowship at Vanderbilt University joint with the departments of Mathematics and Infectious Diseases. Over the past 25 years Dr. Kirschner has focused on questions related to models of host-pathogen interactions in infectious diseases. Her main focus has been to build models of persistent infections (e.g. Helicobacter pylori and Mycobacterium tuberculosis and HIV-1). Her goal is to understand the complex dynamics involved\, together with how perturbations to this interaction (via treatment with chemotherapies or immunotherapies) can lead to prolonged or permanent health. For the past 20 years\, her research focus has been on building multi-scale models to describe the host immune response to M. tuberculosis at multiple spatial and time scales and in multiple physiological compartments including lung\, lymph nodes and blood. \nTo date\, she have worked and collaborated with experimentalists generating data on TB with mouse\, non-human primate and human studies. Denise has over 150 publications in top journals describing this work that spans topics from methodological to biological advancement. Dr. Kirschner currently serves (and has for the past 17 years) as Editor-in-Chief of the Journal of Theoretical Biology. She serves as the founding co-director of The Center for Systems Biology at the University of Michigan\, an interdisciplinary center at the University of Michigan aimed to facilitate research and training between wet-lab and theoretical scientists. In 2016 she was elected as President-elect of the Society for Mathematical Biology and has served as its president from 2017-2020. Denise’s passion for mentoring students\, postdoctoral fellows and junior faculty has been a major focus of her career\, and her key mission is to promote both mathematics and family values in the scientific community.\n \nAPPROACHES FOR STUDYING MULTISCALE COMPUTATIONAL MODELS:  \nMycobacterium tuberculosis is a bacterium that infects 1/3 of the world today. While only 10% of infected individuals experience active tuberculosis disease\, if left untreated infection results in death. The remainder of individuals harbor the bacteria in a clinically latent infection\, and those individuals can experience reactivation of infection up to 10% per year. Our goal in a number of studies is to understand the role of the bacteria in initiating\, sustaining and inhibiting the immune response during infection. Granulomas are a hallmark of tuberculosis infection arising within lungs of infected humans. Understanding the immune response that leads to formation of granulomas can help us better design therapies to control or clear infection. We use a hybrid multi-scale approach that is fine grained for spatial details to help uncover these dynamics paired with a coarse grained spatial model that allows us to capture the entire host dynamics. We use a combination of statistic and mathematical and engineering approaches to predict optimal treatments. \n\nThe MICDE Fall 2020 and Winter 2021 Seminar Series is open to all. University of Michigan faculty and students interested in computational and data sciences are encouraged to attend. \nWatch the full webinar here. \nQuestions? Email MICDE-events@umich.edu
URL:https://micde.umich.edu/event/micde-seminar-denise-kirschner-professor-microbiology-and-immunology-university-of-michigan-medical-school/
LOCATION:Zoom Event
CATEGORIES:Featured Events,MICDE Seminar Series
ATTACH;FMTTYPE=image/png:https://micde.umich.edu/wp-content/uploads/2020/09/Denise-Kirschner.png
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DTSTART;TZID=America/Detroit:20201120T150000
DTEND;TZID=America/Detroit:20201120T160000
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SUMMARY:MICDE / AIM Seminar: Baole Wen\, Assistant Professor\, Mathematics\, University of Michigan
DESCRIPTION:About Baole Wen: Dr. Wen obtained a B.S. degree in Engineering Mechanics and a M.S. degree in Fluid Mechanics\, respectively\, from the Beijing University of Aeronautics and Astronautics.  He was awarded a CEPS Graduate Fellowship \& a Dissertation Year Fellowship and earned a Ph.D. in Applied Mathematics from University of New Hampshire in 2015.  His Ph.D. research was focused on understanding the underlying flow and transport mechanisms governing the spatiotemporally-chaotic system of porous medium convection at large Rayleigh numbers.  Upon graduation\, he was awarded a Peter O’Donnell\, Jr. Postdoctoral Fellowship through the Oden Institute for Computational Engineering and Sciences in the University of Texas at Austin.  His primary research interests are fluid dynamics\, mathematical modeling\, scientific computing and dynamical systems theory.  Recently\, he is working with Dr. Charles Doering as a Postdoctoral Assistant Professor at University of Michigan on extreme behavior in fundamental models of fluid mechanics. \nSTEADY COHERENT STATES IN RAYLEIGH–B\'{E}NARD CONVECTION: Buoyancy-driven flows are central to engineering heat transport\, atmosphere and ocean dynamics\, climate science\, geodynamics\, and stellar physics.   Rayleigh–B\’enard convection—the buoyancy driven flow in a fluid layer heated from below and cooled from above—is recognized as the simplest scenario in which to study such phenomena\, and beyond its importance for applications this problem has served for a century as one of the primary paradigms of nonlinear physics\, complex dynamics\, pattern formation and turbulence.   A central question about Rayleigh–B\’enard convection is how the Nusselt number $Nu$ depends on the Rayleigh number $Ra$ and the Prandtl number $Pr$—i.e.\, how heat flux depends on imposed temperature gradient and the ratio of the fluid’s kinematic viscosity to its thermal diffusivity—as $Ra\rightarrow\infty$.  Experiments and simulations have yet to rule out either `classical’ $Nu \sim Ra^{1/3}$ or `ultimate’ $Nu \sim Ra^{1/2}$ asymptotic scaling.  Here we provide clear quantitative evidence suggesting that the ultimate regime might not exist.  Our tactic is to study relatively simple time-independent states called rolls and compare heat transport by these rolls with that of turbulent convection.  These steady rolls are not typically seen in large-$Ra$ simulations or experiments because they are dynamically unstable.  Nonetheless\, they are part of the global attractor for the infinite-dimensional dynamical system defined by Rayleigh’s model\, and recent results suggest that steady rolls may be one of the key coherent states comprising the `backbone’ of turbulent convection.  By developing novel numerical methods\, we compute steady rolls between no-slip boundaries for $Ra\le 10^{14}$ with $Pr=1$ and various horizontal periods.  We find that rolls of the periods that maximize $Nu$ at each $Ra$ have classical $Nu\sim Ra^{1/3}$ scaling asymptotically\, and they transport more heat than turbulent experiments or simulations at similar parameters.  If turbulent heat transport continues to be dominated by steady transport asymptotically\, it cannot achieve ultimate scaling. \n\nThe MICDE Fall 2020 and Winter 2021 Seminar Series is open to all. University of Michigan faculty and students interested in computational and data sciences are encouraged to attend. \nThis event will be a joint seminar with the University of Michigan Applied Interdisciplinary Mathematics. \nQuestions? Email MICDE-events@umich.edu \nJoin the webinar via the Zoom details below:\nhttps://umich.zoom.us/j/96450383843 \nMeeting ID: 964 5038 3843\nPasscode: 010182
URL:https://micde.umich.edu/event/micde-aim-seminar-baole-wen-assistant-professor-mathematics-university-of-michigan/
LOCATION:Zoom Event
CATEGORIES:Featured Events,MICDE Seminar Series
ATTACH;FMTTYPE=image/png:https://micde.umich.edu/wp-content/uploads/2020/09/Baole-Wen.png
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