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SUMMARY:MICDE Seminar: Margaret Cheung\, Department of Physics\, University of Houston
DESCRIPTION:Bio: Margaret Cheung is an Associate Professor of Physics at the University of Houston. She graduated from the National Taiwan University with a bachelor’s degree in chemistry and received her Ph.D. in physics from the University of California\, San Diego. She carried out theoretical biological physics and bioinformatics research as a Sloan Postdoctoral Fellow at the University of Maryland and started her lab at the University of Houston in 2006. Professor Cheung’s research is in the field of protein folding inside a cell\, calmodulin dependent calcium signaling\, and quantum efficiency in artificial photosynthetic materials. She is particularly interested in developing coarse-grained models for protein dynamics in crowded systems\, creating multi-physics models that bridge dynamics across wide temporal and spatial scales\, and designing computational algorithms that effectively integrate novel high-performance resources. These systems can then be applied for understanding of biological function and for developing therapeutic strategies. She is a fellow of the American Physical Society and a Senior Scientist at the Center for Theoretical Biological Physics at Rice University. \nMolecular Underpinning of Postsynaptic Calmodulin-dependent Calcium Signaling\nCalcium (Ca2+) is exquisitely utilized by a cell for transducing external stimuli through its gradient of extracellular (~1000 μM) and intracellular (~0.1 μM) concentration. A broad spectrum of Ca2+ signals are encoded by protein calmodulin (CaM) through specific binding with various targets regulating CaM-dependent Ca2+ signaling pathways in neurons. I will focus on binding between CaM and two specific targets\, Ca2+/CaM-dependent protein kinase II (CaMKII) and neurogranin (Ng)\, as they antagonistically regulate CaM-dependent Ca2+ signaling pathways in neurons. I will show the impact of bound calmodulin (CaM)-target compound structure on the affinity of calcium (Ca2+) by integrating coarse-grained models and all-atomistic simulations with non-equilibrium physics. We discovered the molecular underpinnings of lowered affinity of Ca2+ for CaM in the presence of Ng by showing that the N-terminal acidic region of Ng peptide pries open the β-sheet structure between the Ca2+ binding loops particularly at C-domain of CaM\, enabling Ca2+ release. In contrast\, CaMKII peptide increases Ca2+ affinity for the C-domain of CaM by stabilizing the two Ca2+ binding loops. Through distinctive structural differences in the bound complexes of apoCaM-Ng13-49 and holoCaM-CaMKII\, CaM’s affinity for Ca2+ is delineated by its progressive mechanism of target binding. I will discuss them in the context of evolution and in the crowded environment. \nProf. Cheung is being hosted by Prof. Geva (Chemistry)
URL:https://micde.umich.edu/event/micde-seminar-margaret-cheung-department-of-physics-university-of-houston/
LOCATION:CHEM 1640\, 930 N University\, Ann Arbor\, MI\, 48109\, United States
CATEGORIES:Featured Events,MICDE Seminar Series,Seminar
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DTSTART;TZID=America/Detroit:20171019T120000
DTEND;TZID=America/Detroit:20171019T133000
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SUMMARY:Mechanical Engineering Seminar: Mark Owkes\, Department of Mechanical and Industrial Engineering\, Montana State University
DESCRIPTION:Bio: Mark Owkes is an Assistant Professor in the department of Mechanical and Industrial Engineering at Montana State University. He earned a BS in Mechanical Engineering from Clarkson University in 2008. He subsequently attained an MS in Mechanical Engineering from the University of Colorado at Boulder in 2011 under the direction of Prof. Olivier Desjardins. He continued his work under Prof. Desjardins at Cornell University where he earned his Ph.D. in May 2014. Mark’s research interests include the development of numerical methods for capturing gas-liquid interfaces in multiphase flow simulations. His simulations of primary atomization provide insight into the physical phenomena important in the break-up of a liquid jet into droplets. Notably\, he has developed both a level set and a volume-of-fluid interface capturing schemes and multiple approaches to compute the curvature of a gas-liquid interface which is important for accurate surface tension forces. \nGas-Liquid Flows: Numerical Methods through Simulations on Supercomputers\nGas-liquid flows exist within many engineering devices including fuel injectors\, wave energy extraction devices\, fire suppression systems\, and PEM fuel cells. Many of these flows are challenging to explore experimentally and computational fluid dynamics (CFD) simulations offer an alternative and useful approach to advance our understanding. For example\, the breakup of liquid fuel into droplets via atomization has a direct effect on combustion efficiency and pollutant formation\, yet a fundamental understanding of the complex process is absent. Laboratory experiments are inherently difficult to conduct because atomizing jets produce a large number of opaque droplets that hinder optical access to the breakup dynamics. With increasing computational resources and advancements in numerical methods\, computational fluid dynamics (CFD) has emerged as a promising tool to investigate the fundamental nature of atomization. In this presentation\, I will present an overview of difficulties arising due to the discontinuities that exist at the gas-liquid interface and recent advances in numerical methods that overcome these challenges. Then I will discuss efforts to improve the the usefulness of the very large data-sets that result from CFD simulations. Details on computing the curvature of a gas-liquid interface\, implementing contact line dynamics\, performing physics extraction\, and coupling gas-liquid flow calculations with uncertainty quantification we be discussed.
URL:https://micde.umich.edu/event/mechanical-engineering-seminar-mark-owkes-department-of-mechanical-and-industrial-engineering-montana-state-university/
LOCATION:1012 EECS\, 1301 Beal Ave\, Ann Arbor\, MI\, 48104\, United States
CATEGORIES:Seminar
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DTSTART;TZID=America/Detroit:20171019T153000
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SUMMARY:MICDE Seminar: Panos Papadopoulos\, Department of Mechanical Engineering\, University of California\, Berkeley
DESCRIPTION:Bio: Panos Papadopoulos is a Professor of Mechanical Engineering at the University of California\, Berkeley\, and director of the Computational Solid Mechanics Laboratory. After obtaining his Diploma in Civil Engineering from the Aristotle University\, Greece\, he moved to California to pursue his graduate studies. He obtained his M. Sc. and Ph.D. in Civil Engineering from UC Berkeley. His research involves experimental\, analytical and computational studies of several mechanics systems. Prof. Papadopoulus develops and applied the finite element method to problems in biomechanics\, dynamics of pseudo-rigid bodies\, mechanics of continues media\, plasticity\, materials science and contact mechanics. \nMultiscale Modeling in Continuum Mechanics: A connection to the Irving-Kirkwood procedure\nThis talk describes a method for extending the classical Irving-Kirkwood procedure used in statistical mechanics for extracting local fluxes to the problem of continuum-on-continuum multiscale modeling. Expressions for stress and heat flux derived here are contrasted to those obtained using the standard Hill-Mandel approach. The polar nature of the macroscopic solid and the role of multiscale invariance are also addressed in the context of this method. Applications are explored within the finite element-based homogenization of solids. \nProf. Papadopoulos is being hosted by Prof. Garikipati (Mechanical Engineering). If you would like to meet with him please send an email to mcteja@umich.edu
URL:https://micde.umich.edu/event/micde-seminar-panos-papadopoulos-department-of-mechanical-engineering-university-of-california-berkeley/
LOCATION:Johnson Rooms\, Lurie Engineering Center\, 3rd Floor LEC 3213ABC\, 1221 Beal Ave.\, Ann Arbor\, MI\, United States
CATEGORIES:Featured Events,MICDE Seminar Series,Seminar
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