The EDSE (Engineering Design and Systems Engineering) program supports fundamental research in design science and systems science. It focuses on advancing knowledge about the design of engineered artifacts, such as devices, products, processes, and systems. The program encourages interdisciplinary collaborations and emphasizes rigorous scientific inquiry into the interactions among designers, artifacts, methods, and the environment. Proposals should be grounded in theory, demonstrate potential for improving design, and include robust methods for assessment. Research areas include design representation, optimization, validation, robotics, materials systems, design cognition, collaboration, data science, and design in various contexts. Prospective investigators are encouraged to consult with the Program Director before proposal submission.