Small and Medium proposals are on a rolling basis from Jan. to Dec. 2022. The CPS program aims to develop the core research needed to engineer these complex CPS, some of which may also require dependable, high-confidence, or provable behaviors. Core research areas of the program include control, data analytics, and machine learningÑincluding real-time learning for control, autonomy, design, Internet of Things (IoT), mixed initiatives including human-in- or human-on-the-loop, networking, privacy, real-time systems, safety, security, and verification. By abstracting from the particulars of specific systems and application domains, the CPS program seeks to reveal cross-cutting, fundamental scientific and engineering principles that underpin the integration of cyber and physical elements across all application domains. The program additionally supports the development of methods, tools, and hardware and software components based upon these cross-cutting principles, along with validation of the principles via prototypes and testbeds. This program also fosters a research community that is committed to advancing education and outreach in CPS and accelerating the transition of CPS research into the real world. Frontier projects must address clearly identified critical CPS challenges that cannot be achieved by a set of smaller projects. Furthermore, Frontier projects should also look to push the boundaries of CPS well beyond today’s systems and capabilities. Funding may be requested for a total of $1,200,001 to $7,000,000 for a period of 4 to 5 years.