The Luker Lab’s research develops and applies quantitative imaging methods to investigate cancer biology and response to therapy. Studies include 4D imaging studies in cell-based assays, mouse models of cancer, and prospective clinical trials. For single cell imaging studies, we focus on extracting multiple quantitative parameters for cell morphology, signaling, movement, cell division, and lineage. We use multi-modality imaging modalities to analyze extent of disease, heterogeneity, and early effects of treatment in mouse models and patients. We track changes in subjects over time, using voxel-wise analysis methods to compare response to therapy. We complement imaging methods with RNA sequencing and proteomics studies with an emphasis on integrating multiple data streams.
Research AreasBiology Applications and Engineering