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Leveraging Generative Artificial Intelligence for the De Novo Design of Biomolecular Probes

Leveraging Generative Artificial Intelligence for the De Novo Design of Biomolecular Probes

by U-M MICDE | Feb 23, 2023

Structure-based drug discovery involves exploring chemical space in search of novel compounds that are likely to bind to and modulate the activity of a biomolecular drug target. There is an urgent need for efficient strategies for exploring chemical space, conditioned...
Exploring Spatiotemporal Biofilm Development Through the Computational Looking Glass

Exploring Spatiotemporal Biofilm Development Through the Computational Looking Glass

by U-M MICDE | Feb 23, 2023

Biofilms are architecturally complex assemblages of microbial cells that form on surfaces that are on and within our bodies and exist on almost every natural and man-made surface. From dental plaque to the “slime” on the hulls of ships, biofilms contain cells that...
Uncovering the Origins of the Local Group of Galaxies with Tailored Initial Conditions

Uncovering the Origins of the Local Group of Galaxies with Tailored Initial Conditions

by U-M MICDE | Feb 23, 2023

The establishment of the standard cosmological model over the past two decades has allowed theorists to explain the origin of the observed distribution of galaxies on large cosmic scales. A self-consistent way to model galaxies is to run simulations that include all...
Accelerated Computation of Resolvent Modes for High-Dimensional Dynamical Systems

Accelerated Computation of Resolvent Modes for High-Dimensional Dynamical Systems

by U-M MICDE | Feb 23, 2023

Turbulence, the disorganized motion of a fluid (often associated with a bumpy ride on an airplane), is ubiquitous in science and engineering, impacting everything from the flight of a golf ball, to fuel efficiency and noise of an engine, to the formation of stars. One...

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